Later on Saturday, league leaders Man City face Leicester. Chelsea will also play away, as they travel to the Hawthorns to face WBA.
Saturday's late fixture will also be an interesting one, with Mourinho's Man United seeking to bounce back from a loss to the hands of Chelsea when they face Newcastle United at their home ground.
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It's set to be another exciting game week in English football's top tier, and here are the matches, prediction for each game and a closer look at the matchday's head fixtures.
Predictions - November 18, 2017, Saturday;
Arsenal vs Tottenham (2 - 2)Bournemouth vs Huddersfield (1 - 1)
Burnley vs Swansea City (1 - 0)
Crystal Palace vs Everton (1 - 1)
Leicester vs Man City (0 - 2)
Liverpool vs Southampton (3 - 1)
WBA vs Chelsea (0 - 3)
Man United vs Newcastle (1 - 0)
Predictions - November 19, 2017, Sunday;
Watford vs West Ham (1 - 0)Predictions - November 20, 2017, Monday;
Brighton vs Stoke City (1 - 0)Arsenal vs Tottenham (2 - 2)
Arsenal's return to winning form after a sluggish start ended last week, as the Gunners were easily defeated 3 - 1 against Guardiola's in-form City squad.
Another tight game is forecasted on Saturday when they face Spurs in north London derby. But if they manage to win Tottenham on Saturday, then they would be only one point behind the Pochetino's team.
Arsenal manager Arsene Wenger benched the club's record signing Alexandre Lacazette out of his starting eleven against Manchester City, but the French striker came on later in the game and managed to score a goal.
So it would be a big surprise if the French striker wasn't included by Wenger again in the starting team, especially with his goalscoring record this term.
Gunner fans and Arsenal players will also expect more from their talisman player Alexis Sanchez. The Chilean international still hasn't found his best form this season and has scored only two goals across all competitions, disappointing.
Spurs, meanwhile, will go into this fixture on the back of a win against Crystal Palace that saw them level on overall points with Man United in the second position but they still trail eight points behind league leaders Manchester City.
Tottenham, however, have injuries to worry about, with some of their key players; Harry Kane, Dele Alli and Harry Winks all having pulled out of England national team through injury.
However, Pochettino has said Harry Kane will be fit enough for the Arsenal clash, although goalkeeper Hugo Lloris and Toby Alderweireld are doubts.
This particular fixture has produced loads of entertainment and goals in recent seasons, and the clash between these two on early Saturday should give us more of the same.
Harry Kane's return is crucial for Tottenham, especially against an Arsenal team that still looks very vulnerable while defending.
However, Tottenham may be without key men between the sticks, Lloris, and in the trio of Lacazette, Ozil, and Sanchez; Arsenal will have the firepower to create their bitter north London rivals some significant problems.
Manchester Utd vs Newcastle Utd (1 - 0)
All eyes will be on Man United's manager Jose Mourinho on Saturday, with the Red Devils in need of a good result after a Man Utd's demoralising defeat from Mourinho's former team Chelsea in the last round.
United team will get a boost by the return from injury of Paul Pogba, who could make the squad.
Newcastle United will prove tough opposition and have fared well on their return to the Premier League - they are in 11th place after 11 games.
Rafael Benitez's side is hard to break down, and United will need to show more creativity and precision in front of goal than they have in recent games if they are to get back to winning ways.